diff --git a/scene/resources/packed_scene.cpp b/scene/resources/packed_scene.cpp
index 786b551b89..1bb46ac37b 100644
--- a/scene/resources/packed_scene.cpp
+++ b/scene/resources/packed_scene.cpp
@@ -347,7 +347,24 @@ Node *SceneState::instantiate(GenEditState p_edit_state) const {
 							node->get_script_instance()->get_property_state(old_state);
 						}
 
-						node->set(snames[nprops[j].name], props[nprops[j].value], &valid);
+#ifdef TOOLS_ENABLED
+						const Ref<Script> value_as_script = props[nprops[j].value];
+						// It is possible that the user changed an existing script to abstract after it was attached to a node.
+						// When this happens, the user needs to fix it. See https://github.com/godotengine/godot/issues/109171
+						if (value_as_script.is_valid() && value_as_script->is_abstract()) {
+							const String global_class_name = value_as_script->get_global_name();
+							if (global_class_name.is_empty()) {
+								ERR_PRINT("Node \"" + snames[n.name] + "\" previously had a script, but that script is now abstract. Please assign a different script (right-click -> Attach Script...) or change the node to a different type (right-click -> Change Type...) to fix this, then re-save the scene.");
+							} else {
+								ERR_PRINT("Node \"" + snames[n.name] + "\" previously had a class of type \"" + global_class_name + "\", but that class is now abstract. Please assign a different script (right-click -> Attach Script...) or change the node to a different type (right-click -> Change Type...) to fix this, then re-save the scene.");
+							}
+							callable_mp((Object *)node, &Object::remove_meta).call_deferred(SceneStringName(_custom_type_script));
+						} else {
+							node->set_script(props[nprops[j].value]);
+						}
+#else
+						node->set_script(props[nprops[j].value]);
+#endif // TOOLS_ENABLED
 
 						//restore old state for new script, if exists
 						for (const Pair<StringName, Variant> &E : old_state) {